In vitro-in vivo correlation studies on a novel controlled release theophylline delivery system and on Theo-Dur tablets
نویسندگان
چکیده
A good correlation should be obtained between data derived from in vitro dissolution and bioavailability studies on drug delivery systems if bioavailability parameters are to be reliably predicted from the in vitro dissolution variables. This study compares the in vivo absorption with the in vitro dissolution profiles into various dissolution media of a novel controlled release theophylline capsule (Mintab) containing mini-matrices, and also those of Theo-Dur 300 mg tablets. Mintab displayed significant pharmacokinetic advantages over Thco-Dur. However. Theo-Dur demonstrated good in vitro-in vivo correlation, whereas Mintab showed poor correlation.
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